Alzheimer's Disease: Modelization, Biomarkers, Preclinical Imaging, Therapeutic Evaluations
Resp. Marc Dhenain
UMR CEA CNRS 9199, MIRCen, 18 Route du Panorama, 92265 Fontenay aux Roses, France
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Team Members
| Marc Dhenain (DR2, CNRS)
Marc Dhenain is a Doctor in Veterinary Medicine, Ph.D.. After an initial training based on the characterization of age-related behavioral impairments in mouse lemur primates, Dr. Dhenain learned MR methods at CALTECH, Pasadena, USA where he first used MR methods to detect amyloid deposition in human brains. Marc Dhenain is now specialized in the study of animal models (rodents and Primates) of cerebral aging and Alzheimer's disease by imaging methods (MRI, PET). His studies have provided significant knowledge on AD-like pathology in animals including mouse lemur Primates and also described new innovative protocols to image amyloid plaques by MRI. MD is corresponding member of the Veterinary Academy of France.
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| Jean-Luc Picq (Professor, University Paris VIII)
Jean-Luc Picq is Ph.D. in behavioral studies. He characterizes age-related behavioral impairments in mouse lemur primates as well as cerebral atrophy patterns in these animals. He showed for the first time in a primate, a relationship between cognitive alteration and age-associated cerebral atrophy.
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| Fanny Petit (Technician, Histology, CEA)
Fanny Petit is a technician specialized in histological evaluation of neurodegerenative diseases. She develop and optimize the histological stains performed in our group.
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| Nachiket Nadkarni (Post-Doc, ROMANE Project)
Nachiket Nadkarni has a Ph.D. of Clinical Medicine Research obtained at the Imperial College London, UK. He is a neurobiologist specialist of the conception and implementation of clinical studies; functional and anatomical MRI in humans and animals. He is currently evaluating, thanks to MRI, a new therapy against Alzheimer's disease in a preclinical and phaase III clinical trial.
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| Salma Bougacha (Post-Doc, Amylnet Project)
Salma Bougacha, Ph.D., is a mathematician specialist of the evaluation of neuronal netwoks and image processing. She is currently evaluating new methods to evaluate relationships between amyloid and neuronal networks alterations.
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| Clément Garin (Dr. in Pharmacy, Graduate, Amylnet Project)
Clément Garin is a Pharmacist and a neurobiologist. He evaluates processes that accelerate cerebral aging and Alzheimer pathology in mice as well as the impact of amyloid on neuronal networks. He focuses in particular on the Prion hypothesis of Alzheimer's disease.
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| Clémence Dudeffant (Graduate, Gd-Stain, Llamalz)
Clémence Dudeffan is a pharmacist. is a Pharmacist and a neurobiologist. She evaluates new methods to detect amyloid plaques by MRI.
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| Suzanne Lam (Graduate, InductAlz project)
Suzanne Lamis a Pharmacist and a neurobiologist. She evaluates processes that accelerate cerebral aging and Alzheimer pathology in the mouse lemur primate and in mice. She focuses in particular on the Prion hypothesis of Alzheimer's disease.
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Former Team Members
| James Koch
(Associate Professor, University of Wisconsin, Oshkosh)
James Koch is PhD. in physiological psychology. In the lab, he characterized cerebral aging in mouse lemur primates and evaluated new mechanisms involved in the development of Alzheimer's disease. He also evaluated new imaging methods to detect amyloid plaques by MRI.
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| Matthias Vandesquille (Post-Doc, LLAMALZ Project)
Matthias Vandesquille, Ph.D., is a neurobiologist specialist of the evaluation of animal models and new therapy targeting age-related brain diseases. He is evaluated new methods to detect amyloid plaques by MRI.
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| Charlotte Gary (Dr. in Pharmacy, Graduate, InductAlz Project)
Charlotte Gary is a Pharmacist and a neurobiologist. She evaluates processes that accelerate cerebral aging and Alzheimer pathology in the mouse lemur primate and in mice. She focuses in particular on the Prion hypothesis of Alzheimer's disease.
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| Zoé Hanss (Undergraduate student)
Zoé Hanss is a Pharmacist and a neurobiologist. She evaluateed processes that accelerate cerebral aging and Alzheimer pathology in the mouse lemur primate and in mice. She focuses in particular on the Prion hypothesis of Alzheimer's disease..
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| Lisa Ciaptacz (Undergraduate student)
Lisa Ciaptacz is a neurobiologist. She evaluated processes that accelerate cerebral aging and Alzheimer pathology in mice. She focused in particular on the Prion hypothesis of Alzheimer's disease.
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| Emmalaurie Baptiste (Undergraduate student)
Emmanaurie Baptiste is a neurobiologist. She evaluated tye role of mast-cell on neurodegerenative processes.
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| Mireilla Peterson (Undergraduate student, ROMANE project)
Mireilla Peterson is a neurobiologist. She evaluates, by MRI, alterations of cerebral perfusion associated to Alzheimer's disease in animal models and studies the effects of a therapy on this perfusion.
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| Kelly Herbert (Undergraduate student, Alliance Biosec. Project)
Kelly Herbert is a neurobiologist. She evaluates a new method to detect amyloid plaques, including Prion lesions, by MRI.
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| Christelle Po (Post-Doc, LLAMALZ Project)
Chrystelle Po, Ph.D., is a specialist of MRI and of the evaluation of animal models of cerebral pathologies by MRI. She evaluated a new method to detect amyloid plaques by MRI. She is now in charge of the 11.7 Tesla MRI of the Biomedical Magnetic Resonance Unit (REMA) at the Université Catholique de Louvain (Belgium).
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| Mathieu Santin (Ph.D., former post-doc)
Mathieu Santin evaluated new protocols to detect amyloid plaques by MRI and followed-up therapies effects with the developped protocols. He is currently responsable of the 11.7 Tesla MRI in the ICM Institute.
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| Alexandra Petiet (Ph.D., former post-doc)
Alexandra Petiet evaluated new protocols to detect amyloid plaques by MRI. she is currently scientific responsable of the 11.7Tesla MRI in the ICM Institute.
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| Audrey Kraska (Dr. in Pharmacy, Ph.D.)
Audrey Kraska is a Pharmacist, Ph.D.. During her thesis, she evaluated processes that accelerate cerebral aging in the mouse lemur primate.
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| Nelly Joseph Mathurin (University Paris VI, ED3C, PhD)
Nelly Joseph-Mathurin finished a Ph.D study dedicatd to the evaluation of an immunotherapy in mouse lemur primates.
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| Olene Dorieux (University Paris VI, GC2ID)
Olene Dorieux is currently fisnishing a Ph.D study dedicatd to the evaluation of a trophic factor on cerebral metabolism in mouse lemur primates. She implemented a protocol to evaluate the brain of mouse lemurs by PET.
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| Anne Bertrand (University Paris VI, ED3C)
Anne Bertrand is a radiologist. She is currently fisnishing a Ph.D study dedicatd to the development of new imaging protocols to follow-up neuronal alterations as well as to perform MR microscopy in animal models of Alzheimer's disease.
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| Geraldine Poisnel (Ph.D., former post-doc)
Geraldine Poisnel evaluated new protocols to detect amyloid plaques by PET and to follow-up metabolic alterations associated to amyloid. She has then been recruited by SERVIER as a research scientist.
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| Oliviero Gobbo (Ph.D., former visiting research fellow)
Oliviero Gobbo implemented a new protocol based on MEMRI to follow-up cerebral alterations induced by neuroinflammation. He is currently working at the School of Pharmacy and Pharmaceutical Sciences of the Trinity College of Dublin.
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| Cecile Cardoso (University Paris Sud, Master Cellular Signalisation and Neurosciences)
Cecile Cardoso characterized cerebral aging in mouse lemur primates and evaluated biomarkers of cerebral aging in these animals. She then took a position of assistant engineer at the Inserm U740 'Génétique des Maladies Vasculaires' in Paris.
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| Maggie Roy (University Paris, Master Neurosciences)
During her master, Maggie Roy evaluated plasmatic biomarker for Alzheimer’s disease in mice and primate models. She is currently in Thesis at the Centre de Recherche sur le Vieillissement (Sherbrooke, Canada).
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| Adrien Pasquier (University Paris, Master Biology of Aging)
During his master, Adrien Pasquier evaluated the detection of microscopic lesions of Alzheimer's disease in a primate model. He then became product manager in the Codepharma laboratories.
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| Myriam Ly (University Paris, Master Neurosciences)
During her master, Myriam Ly evaluated a process that accelerates cerebral aging in primates. She then performed a PhD entitled "Analyse clinico-pathologique de modèles murins de la Maladie d’Alzheimer pour l’identification de cibles thérapeutiques" at the Brain and Spine Institute (Paris).
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